5x8x

X-ray diffraction
2.6Å resolution

Crystal Structure of the mutant Human ROR gamma Ligand Binding Domain With Compound A.

Released:

Function and Biology Details

Structure analysis Details

Assembly composition:
hetero dimer (preferred)
PDBe Complex ID:
PDB-CPX-124206 (preferred)
Entry contents:
2 distinct polypeptide molecules
Macromolecules (2 distinct):
RAR related orphan receptor C Chains: A, C, E, G
Molecule details ›
Chains: A, C, E, G
Length: 258 amino acids
Theoretical weight: 29.75 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: G1RH57 (Residues: 240-497; Coverage: 52%)
Gene name: RORC
Sequence domains: Ligand-binding domain of nuclear hormone receptor
Structure domains: Retinoid X Receptor
Nuclear receptor corepressor 2 Chains: B, D, F, H
Molecule details ›
Chains: B, D, F, H
Length: 22 amino acids
Theoretical weight: 2.6 KDa
Source organism: Homo sapiens
Expression system: synthetic construct
UniProt:
  • Canonical: Q9Y618 (Residues: 2335-2356; Coverage: 1%)
Gene names: CTG26, NCOR2

Ligands and Environments

1 bound ligand:
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: SPRING-8 BEAMLINE BL41XU
Spacegroup: P21
Unit cell:
a: 79.3Å b: 72.6Å c: 99.32Å
α: 90° β: 89.98° γ: 90°
R-values:
R R work R free
0.2 0.199 0.233
Expression systems:
  • Escherichia coli
  • synthetic construct