› 5xbk

X-ray diffraction
3.22Å resolution

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assemblies composition:
monomeric
hetero dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-160858 (preferred)
Entry contents:
2 distinct polypeptide molecules
Macromolecules (2 distinct):
Importin-4 Chains: A, B, C, D
Molecule details ›
Chains: A, B, C, D
Length: 416 amino acids
Theoretical weight: 44.84 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli 'BL21-Gold(DE3)pLysS AG'
UniProt:
  • Canonical: Q8TEX9 (Residues: 668-1081; Coverage: 38%)
Gene names: IMP4B, IPO4, RANBP4
Sequence domains: HEAT-like repeat
Histone H3.2 Chain: E
Molecule details ›
Chain: E
Length: 18 amino acids
Theoretical weight: 1.95 KDa
Source organism: Xenopus laevis
Expression system: Escherichia coli 'BL21-Gold(DE3)pLysS AG'
UniProt:
  • Canonical: P84233 (Residues: 2-19; Coverage: 13%)

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: PAL/PLS BEAMLINE 5C (4A)
Spacegroup: P21
Unit cell:
a: 65.021Å b: 108.536Å c: 124.86Å
α: 90° β: 103.41° γ: 90°
R-values:
R R work R free
0.225 0.218 0.281
Expression system: Escherichia coli 'BL21-Gold(DE3)pLysS AG'

Quick links

Citations

5 review citations

H3-H4 Histone Chaperone Pathways.
Grover et al. (2018)
4 more

2 mentions without citation

Nuclear import of histones.
Bernardes et al. (2020)
1 more