› 5xdk

X-ray diffraction
2.35Å resolution

Crystal structure of EGFR 696-1022 T790M in complex with CO-1686

Released:
DOI: 10.2210/pdb5xdk/pdb
PDB entry 5xdk coloured by chain, front view.
PDB entry 5xdk coloured by chain, side view.
PDB entry 5xdk coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Structural basis of mutant-selectivity and drug-resistance related to CO-1686.
Yan XE, Zhu SJ, Liang L, Zhao P, Choi HG, Yun CH
Oncotarget 8 53508-53517 (2017)
PMID: 28881827

Function and Biology Details

Reaction catalysed: 
ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate
Biochemical function:
Biological process:
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-132671 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Epidermal growth factor receptor Chain: A
Molecule details ›
Chain: A
Length: 331 amino acids
Theoretical weight: 37.65 KDa
Source organism: Homo sapiens
Expression system: Spodoptera frugiperda
UniProt:
  • Canonical: P00533 (Residues: 696-1022; Coverage: 28%)
Gene names: EGFR, ERBB, ERBB1, HER1
Sequence domains: Protein tyrosine and serine/threonine kinase
Structure domains:

Ligands and Environments

1 bound ligand:
Ligand 8JC 1 x 8JC
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: SSRF BEAMLINE BL18U1
Spacegroup: I23
Unit cell:
a: 145.471Å b: 145.471Å c: 145.471Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.219 0.217 0.248
Expression system: Spodoptera frugiperda

Quick links

Citations

3 review citations

Emerging strategies to overcome resistance to third-generation EGFR inhibitors.
Shi et al. (2022)
2 more

4 mentions without citation

Structural insights into drug development strategy targeting EGFR T790M/C797S.
Zhu et al. (2018)
3 more