› 5xhz

X-ray diffraction
1.32Å resolution

Crystal Structure Analysis of CIN85-SH3B in complex with ARAP1-P2

Released:
DOI: 10.2210/pdb5xhz/pdb
PDB entry 5xhz coloured by chain, front view.
PDB entry 5xhz coloured by chain, side view.
PDB entry 5xhz coloured by chain, top view.
Source organism: Mus musculus
Primary publication:
Biochemical and Structural Studies of the Interaction between ARAP1 and CIN85.
Li Q, Yang W, Wang Y, Liu W
Biochemistry 57 2132-2139 (2018)
PMID: 29589748

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
hetero dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-175652 (preferred)
Entry contents:
2 distinct polypeptide molecules
Macromolecules (2 distinct):
SH3 domain-containing kinase-binding protein 1 Chains: A, B
Molecule details ›
Chains: A, B
Length: 66 amino acids
Theoretical weight: 7.48 KDa
Source organism: Mus musculus
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: Q8R550 (Residues: 98-157; Coverage: 9%)
Gene names: Ruk, Seta, Sh3kbp1
Sequence domains: Variant SH3 domain
Structure domains: SH3 Domains
Arf-GAP with Rho-GAP domain, ANK repeat and PH domain-containing protein 1 Chains: C, D
Molecule details ›
Chains: C, D
Length: 11 amino acids
Theoretical weight: 1.44 KDa
Source organism: Mus musculus
Expression system: Not provided
UniProt:
  • Canonical: Q4LDD4 (Residues: 80-90; Coverage: 1%)
Gene names: Arap1, Centd2, Kiaa0782

Ligands and Environments

1 bound ligand:
Ligand ACT 1 x ACT
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: SSRF BEAMLINE BL19U1
Spacegroup: P43
Unit cell:
a: 66.162Å b: 66.162Å c: 34.935Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.164 0.163 0.187
Expression systems:
  • Escherichia coli BL21(DE3)
  • Not provided

Quick links

Citations

6 citation in other articles

LncRNA ARAP1-AS2 promotes high glucose-induced human proximal tubular cell injury via persistent transactivation of the EGFR by interacting with ARAP1.
Li et al. (2020)
5 more