› 5xjv

X-ray diffraction
1.69Å resolution

Two intermediate states of conformation switch in dual specificity phosphatase 13a

Released:
DOI: 10.2210/pdb5xjv/pdb
PDB entry 5xjv coloured by chain, front view.
PDB entry 5xjv coloured by chain, side view.
PDB entry 5xjv coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Two intermediate states of the conformational switch in dual specificity phosphatase 13a.
Wei CH, Min HG, Kim M, Kim GH, Chun HJ, Ryu SE
Pharmacol Res 128 211-219 (2018)
PMID: 29106959

Function and Biology Details

Reactions catalysed: 
[a protein]-serine/threonine phosphate + H(2)O = [a protein]-serine/threonine + phosphate
Protein tyrosine phosphate + H(2)O = protein tyrosine + phosphate
Biochemical function:
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-179414 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Dual specificity protein phosphatase 13A Chains: A, B
Molecule details ›
Chains: A, B
Length: 185 amino acids
Theoretical weight: 20.27 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: Q6B8I1 (Residues: 1-185; Coverage: 98%)
Gene names: BEDP, DUSP13, DUSP13A, MDSP
Sequence domains: Dual specificity phosphatase, catalytic domain
Structure domains: Protein tyrosine phosphatase superfamily

Ligands and Environments

1 bound ligand:
Ligand PO4 2 x PO4
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: PAL/PLS BEAMLINE 7A (6B, 6C1)
Spacegroup: P21
Unit cell:
a: 40.037Å b: 89.343Å c: 45.897Å
α: 90° β: 89.88° γ: 90°
R-values:
R R work R free
0.18 0.178 0.221
Expression system: Escherichia coli

Quick links

Citations

1 mention without citation

In Vitro and In Silico Investigation of BCI Anticancer Properties and Its Potential for Chemotherapy-Combined Treatments.
Marciniak et al. (2023)