› 5xmj

X-ray diffraction
3.6Å resolution

Function and Biology Details

Reaction catalysed: 
Succinate + a quinone = fumarate + a quinol
Biochemical function:
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
hetero hexamer (preferred)
PDBe Complex ID:
PDB-CPX-197505 (preferred)
Entry contents:
3 distinct polypeptide molecules
Macromolecules (3 distinct):
succinate dehydrogenase Chains: A, E, I, M
Molecule details ›
Chains: A, E, I, M
Length: 627 amino acids
Theoretical weight: 68.76 KDa
Source organism: Megalodesulfovibrio gigas
UniProt:
  • Canonical: T2GB49 (Residues: 1-627; Coverage: 100%)
Gene names: DGI_1569, fdrA
Sequence domains:
Fumarate reductase iron-sulfur subunit Chains: B, F, J, N
Molecule details ›
Chains: B, F, J, N
Length: 264 amino acids
Theoretical weight: 29.7 KDa
Source organism: Megalodesulfovibrio gigas DSM 1382 = ATCC 19364
UniProt:
  • Canonical: T2G9X8 (Residues: 1-264; Coverage: 100%)
Gene names: DGI_1570, fdrB
Sequence domains:
Structure domains:
Putative Fumarate reductase respiratory complex Chains: C, G, K, O
Molecule details ›
Chains: C, G, K, O
Length: 218 amino acids
Theoretical weight: 24.73 KDa
Source organism: Megalodesulfovibrio gigas
UniProt:
  • Canonical: T2GAT5 (Residues: 1-218; Coverage: 100%)
Gene names: DGI_1568, fdrC
Sequence domains: Succinate dehydrogenase/Fumarate reductase transmembrane subunit

Ligands and Environments


Cofactor: Ligand HEM 8 x HEM

Cofactor: Ligand FAD 4 x FAD
6 bound ligands:
Ligand FUM 4 x FUM
Ligand F3S 4 x F3S
Ligand SF4 4 x SF4
Ligand FES 4 x FES
Ligand LMT 2 x LMT
Ligand MQ7 1 x MQ7
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: SPRING-8 BEAMLINE BL44XU
Spacegroup: P21
Unit cell:
a: 112.136Å b: 131.772Å c: 195.428Å
α: 90° β: 94.22° γ: 90°
R-values:
R R work R free
0.236 0.232 0.313

Quick links

Citations

1 review citation

Genomic insight into iron acquisition by sulfate-reducing bacteria in microaerophilic environments.
Barton et al. (2023)
3 other articles

2 mentions without citation

Structural insights into the electron/proton transfer pathways in the quinol:fumarate reductase from Desulfovibrio gigas.
Guan et al. (2018)
1 more