Function and Biology Details
Biochemical function:
Biological process:
Cellular component:
Structure analysis Details
Assembly composition:
hetero hexamer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-131075 (preferred)
Entry contents:
2 distinct polypeptide molecules
Macromolecules (2 distinct):
Mothers against decapentaplegic homolog 3
Molecule details ›
Chain: A
Length: 199 amino acids
Theoretical weight: 22.46 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
Sequence domains: MH2 domain
Structure domains: Tumour Suppressor Smad4
Length: 199 amino acids
Theoretical weight: 22.46 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
- Canonical:
P84022 (Residues: 220-416; Coverage: 46%)
Sequence domains: MH2 domain
Structure domains: Tumour Suppressor Smad4
Forkhead box protein H1; Thioredoxin 1
Molecule details ›
Chain: B
Length: 141 amino acids
Theoretical weight: 15.44 KDa
Source organisms: Expression system: Escherichia coli
UniProt:
Sequence domains: Thioredoxin
Length: 141 amino acids
Theoretical weight: 15.44 KDa
Source organisms: Expression system: Escherichia coli
UniProt:
- Canonical: P0AA25 (Residues: 2-109; Coverage: 99%)
- Canonical: O75593 (Residues: 322-345; Coverage: 7%)
Sequence domains: Thioredoxin
Ligands and Environments
No bound ligands
No modified residues
Experiments and Validation Details
X-ray source:
PHOTON FACTORY BEAMLINE AR-NE3A
Spacegroup:
P6322
Expression system: Escherichia coli
