› 5xq1

X-ray diffraction
2.95Å resolution

Structural basis of kindlin-mediated integrin recognition and activation

Released:
DOI: 10.2210/pdb5xq1/pdb
PDB entry 5xq1 coloured by chain, front view.
PDB entry 5xq1 coloured by chain, side view.
PDB entry 5xq1 coloured by chain, top view.
Source organism: Mus musculus
Primary publication:
Structural basis of kindlin-mediated integrin recognition and activation.
Li H, Deng Y, Sun K, Yang H, Liu J, Wang M, Zhang Z, Lin J, Wu C, Wei Z, Yu C
Proc Natl Acad Sci U S A 114 9349-9354 (2017)
PMID: 28739949

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
homo dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-129516 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Fermitin family homolog 2; Integrin beta-3 Chains: A, B
Molecule details ›
Chains: A, B
Length: 485 amino acids
Theoretical weight: 56.13 KDa
Source organism: Mus musculus
Expression system: Escherichia coli
UniProt:
  • Canonical: Q8CIB5 (Residues: 1-680; Coverage: 67%)
  • Canonical: O54890 (Residues: 773-787; Coverage: 2%)
Gene names: Fermt2, Itgb3, Plekhc1
Sequence domains:

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: SSRF BEAMLINE BL19U1
Spacegroup: P3221
Unit cell:
a: 75.973Å b: 75.973Å c: 387.042Å
α: 90° β: 90° γ: 120°
R-values:
R R work R free
0.222 0.22 0.26
Expression system: Escherichia coli

Quick links

Citations

25 review citations

Integrin activation by talin, kindlin and mechanical forces.
Sun et al. (2019)
24 more

4 mentions without citation

Structural basis of kindlin-mediated integrin recognition and activation.
Li et al. (2017)
3 more