› 5xts

X-ray diffraction
2Å resolution

Crystal structure of the CysR-CTLD3 fragment of human MR at basic/neutral pH

Released:
DOI: 10.2210/pdb5xts/pdb
PDB entry 5xts coloured by chain, front view.
PDB entry 5xts coloured by chain, side view.
PDB entry 5xts coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Structural Insights into the pH-Dependent Conformational Change and Collagen Recognition of the Human Mannose Receptor.
Hu Z, Shi X, Yu B, Li N, Huang Y, He Y
Structure 26 60-71.e3 (2018)
PMID: 29225077

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-149836 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Macrophage mannose receptor 1 Chain: A
Molecule details ›
Chain: A
Length: 614 amino acids
Theoretical weight: 70.54 KDa
Source organism: Homo sapiens
Expression system: Trichoplusia ni
UniProt:
  • Canonical: P22897 (Residues: 22-629; Coverage: 42%)
Gene names: CLEC13D, CLEC13DL, MRC1, MRC1L1
Sequence domains:

Ligands and Environments

1 bound ligand:
Ligand CA 1 x CA
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: NFPSS BEAMLINE BL19U1
Spacegroup: P212121
Unit cell:
a: 60.256Å b: 101.697Å c: 123.464Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.167 0.166 0.201
Expression system: Trichoplusia ni

Quick links

Citations

4 review citations

Macrophage Activation Markers, CD163 and CD206, in Acute-on-Chronic Liver Failure.
Nielsen et al. (2020)
3 more

4 mentions without citation

Molecular Recognition in C-Type Lectins: The Cases of DC-SIGN, Langerin, MGL, and L-Sectin.
Valverde et al. (2020)
3 more