› 5xwm

X-ray diffraction
2.45Å resolution

human ERp44 zinc-bound form

Released:
DOI: 10.2210/pdb5xwm/pdb
PDB entry 5xwm coloured by chain, front view.
PDB entry 5xwm coloured by chain, side view.
PDB entry 5xwm coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Zinc regulates ERp44-dependent protein quality control in the early secretory pathway.
Watanabe S, Amagai Y, Sannino S, Tempio T, Anelli T, Harayama M, Masui S, Sorrentino I, Yamada M, Sitia R, Inaba K
Nat Commun 10 603 (2019)
PMID: 30723194

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
homo dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-189700 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Endoplasmic reticulum resident protein 44 Chains: A, B, C, D
Molecule details ›
Chains: A, B, C, D
Length: 383 amino acids
Theoretical weight: 44.35 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: Q9BS26 (Residues: 30-406; Coverage: 100%)
Gene names: ERP44, KIAA0573, TXNDC4, UNQ532/PRO1075
Sequence domains:

Ligands and Environments

2 bound ligands:
Ligand ZN 10 x ZN
Ligand CL 8 x CL
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: SPRING-8 BEAMLINE BL44XU, PHOTON FACTORY BEAMLINE BL-1A
Spacegroup: P6122
Unit cell:
a: 175.15Å b: 175.15Å c: 407.81Å
α: 90° β: 90° γ: 120°
R-values:
R R work R free
0.184 0.182 0.214
Expression system: Escherichia coli

Quick links

Citations

7 review citations

Zinc transporters and their functional integration in mammalian cells.
Kambe et al. (2021)
6 more

2 mentions without citation

Ero1α-Dependent ERp44 Dissociation From RyR2 Contributes to Cardiac Arrhythmia.
Hamilton et al. (2022)
1 more