› 5xy1

X-ray diffraction
2.7Å resolution

Crystal structure of Lyn kinase domain in complex with N-(1H-indazol-6-yl)-8-(piperidin-4-yloxy)-6-propylquinazolin-2-amine

Released:
DOI: 10.2210/pdb5xy1/pdb
PDB entry 5xy1 coloured by chain, front view.
PDB entry 5xy1 coloured by chain, side view.
PDB entry 5xy1 coloured by chain, top view.
Source organism: Homo sapiens
Entry author: Kim HT

Function and Biology Details

Reaction catalysed: 
ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate
Biochemical function:
Biological process:
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-139851 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Tyrosine-protein kinase Lyn Chain: A
Molecule details ›
Chain: A
Length: 279 amino acids
Theoretical weight: 31.8 KDa
Source organism: Homo sapiens
Expression system: Insect cell expression vector pTIE1
UniProt:
  • Canonical: P07948 (Residues: 239-512; Coverage: 54%)
Gene names: JTK8, LYN
Sequence domains: Protein tyrosine and serine/threonine kinase
Structure domains:

Ligands and Environments

1 bound ligand:
Ligand 8H0 1 x 8H0
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: PAL/PLS BEAMLINE 5C (4A)
Spacegroup: R3
Unit cell:
a: 128.864Å b: 128.864Å c: 55.123Å
α: 90° β: 90° γ: 120°
R-values:
R R work R free
0.216 0.214 0.26
Expression system: Insect cell expression vector pTIE1

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