› 5y4d

X-ray diffraction
3.3Å resolution

Crystal Structure of AnkB Ankyrin Repeats in Complex with AnkR/AnkB Chimeric Autoinhibition Segment

Released:
DOI: 10.2210/pdb5y4d/pdb
PDB entry 5y4d coloured by chain, front view.
PDB entry 5y4d coloured by chain, side view.
PDB entry 5y4d coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Autoinhibition of ankyrin-B/G membrane target bindings by intrinsically disordered segments from the tail regions.
Chen K, Li J, Wang C, Wei Z, Zhang M
Elife 6 (2017)
PMID: 28841137

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-241968 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Ankyrin-2 Chain: A
Molecule details ›
Chain: A
Length: 731 amino acids
Theoretical weight: 78.03 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: Q01484 (Residues: 28-693; Coverage: 17%)
Gene names: ANK2, ANKB
Sequence domains: Ankyrin repeat

Ligands and Environments

1 bound ligand:
Ligand SO4 10 x SO4
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: SSRF BEAMLINE BL17U1
Spacegroup: R32
Unit cell:
a: 179.787Å b: 179.787Å c: 227.098Å
α: 90° β: 90° γ: 120°
R-values:
R R work R free
0.188 0.183 0.229
Expression system: Escherichia coli

Quick links

Citations

3 review citations

Ankyrins: Roles in synaptic biology and pathology.
Smith et al. (2018)
2 more

3 mentions without citation

Diversity and function of arthropod endosymbiont toxins.
Massey et al. (2022)
2 more