› 5y8v

X-ray diffraction
2.61Å resolution

Crystal structure of GAS41

Released:
DOI: 10.2210/pdb5y8v/pdb
PDB entry 5y8v coloured by chain, front view.
PDB entry 5y8v coloured by chain, side view.
PDB entry 5y8v coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Identification of the YEATS domain of GAS41 as a pH-dependent reader of histone succinylation.
Wang Y, Jin J, Chung MWH, Feng L, Sun H, Hao Q
Proc Natl Acad Sci U S A 115 2365-2370 (2018)
PMID: 29463709

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-131952 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
YEATS domain-containing protein 4 Chains: A, B, C, D
Molecule details ›
Chains: A, B, C, D
Length: 140 amino acids
Theoretical weight: 16.57 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli-Pichia pastoris shuttle vector pPpARG4
UniProt:
  • Canonical: O95619 (Residues: 21-160; Coverage: 62%)
Gene names: GAS41, YEATS4
Sequence domains: YEATS family
Structure domains: YEATS domain

Ligands and Environments

1 bound ligand:
Ligand MG 4 x MG
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: NSRRC BEAMLINE BL13C1
Spacegroup: P212121
Unit cell:
a: 55.467Å b: 57.212Å c: 205.854Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.239 0.237 0.28
Expression system: Escherichia coli-Pichia pastoris shuttle vector pPpARG4

Quick links

Citations

22 review citations

The evolving metabolic landscape of chromatin biology and epigenetics.
Dai et al. (2020)
21 more

1 mention without citation

Identification of the YEATS domain of GAS41 as a pH-dependent reader of histone succinylation.
Wang et al. (2018)