› 5ygh

X-ray diffraction
1.88Å resolution

Crystal Structure of the Capsid Protein from Zika Virus

Released:
DOI: 10.2210/pdb5ygh/pdb
PDB entry 5ygh coloured by chain, front view.
PDB entry 5ygh coloured by chain, side view.
PDB entry 5ygh coloured by chain, top view.
Source organism: Zika virus
Primary publication:
Crystal Structure of the Capsid Protein from Zika Virus.
Shang Z, Song H, Shi Y, Qi J, Gao GF
J Mol Biol 430 948-962 (2018)
PMID: 29454707

Function and Biology Details

Reactions catalysed: 
Selective hydrolysis of -Xaa-Xaa-|-Yaa- bonds in which each of the Xaa can be either Arg or Lys and Yaa can be either Ser or Ala.
NTP + H(2)O = NDP + phosphate
ATP + H(2)O = ADP + phosphate
Biochemical function:
Biological process:
  • not assigned
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
homo dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-102816 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Capsid protein Chains: A, B
Molecule details ›
Chains: A, B
Length: 76 amino acids
Theoretical weight: 8.4 KDa
Source organism: Zika virus
Expression system: Escherichia coli BL21
UniProt:
  • Canonical: A0A0X8GJ44 (Residues: 23-98; Coverage: 2%)
Sequence domains: Flavivirus capsid protein C
Structure domains: Arc Repressor Mutant, subunit A

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: SSRF BEAMLINE BL17U1
Spacegroup: P63
Unit cell:
a: 69.417Å b: 69.417Å c: 58.07Å
α: 90° β: 90° γ: 120°
R-values:
R R work R free
0.207 0.206 0.23
Expression system: Escherichia coli BL21

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Citations

28 review citations

Intrinsically disordered proteins of viruses: Involvement in the mechanism of cell regulation and pathogenesis.
Mishra et al. (2020)
27 more

12 mentions without citation

Tick-Borne Encephalitis Virus: A Structural View.
Pulkkinen et al. (2018)
11 more