› 5yhn

Solution NMR

Solution structure of the LEKTI Domain 4

Released:
DOI: 10.2210/pdb5yhn/pdb
PDB entry 5yhn coloured by chain, ensemble of 20 models, front view.
PDB entry 5yhn coloured by chain, ensemble of 20 models, side view.
PDB entry 5yhn coloured by chain, ensemble of 20 models, top view.
Source organism: Homo sapiens
Primary publication:
Homologous Lympho-Epithelial Kazal-type Inhibitor Domains Delay Blood Coagulation by Inhibiting Factor X and XI with Differential Specificity.
Ramesh K, Lama D, Tan KW, Nguyen VS, Chew FT, Verma CS, Mok YK
Structure 26 1178-1186.e3 (2018)
PMID: 30017565

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-192495 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Serine protease inhibitor Kazal-type 5 Chain: A
Molecule details ›
Chain: A
Length: 69 amino acids
Theoretical weight: 8.03 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: Q9NQ38 (Residues: 220-288; Coverage: 7%)
Gene name: SPINK5
Sequence domains: Kazal-type serine protease inhibitor domain

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
Chemical shift assignment: 48%
Refinement method: simulated annealing
Expression system: Escherichia coli

Quick links

Citations

3 citation in other articles

Crystal structure of Aedes aegypti trypsin inhibitor in complex with μ-plasmin reveals role for scaffold stability in Kazal-type serine protease inhibitor.
Walvekar et al. (2022)
2 more