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› 5yhy

X-ray diffraction
1.65Å resolution

Structure of Lactococcus lactis ZitR, C30S mutant

Released:
DOI: 10.2210/pdb5yhy/pdb
Model geometry
Fit model/data
PDB entry 5yhy coloured by chain, front view.
PDB entry 5yhy coloured by chain, side view.
PDB entry 5yhy coloured by chain, top view.
Source organism: Lactococcus lactis subsp. lactis Il1403
Primary publication:
Allosteric histidine switch for regulation of intracellular zinc(II) fluctuation.
Zhu R, Song Y, Liu H, Yang Y, Wang S, Yi C, Chen PR
Proc Natl Acad Sci U S A 114 13661-13666 (2017)
PMID: 29229866

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
homo dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-189952 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
HTH marR-type domain-containing protein Chain: A
Molecule details ›
Chain: A
Length: 146 amino acids
Theoretical weight: 16.43 KDa
Source organism: Lactococcus lactis subsp. lactis Il1403
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: Q9CDU5 (Residues: 1-145; Coverage: 100%)
Gene names: L168265, zitR
Sequence domains: MarR family

Ligands and Environments

1 bound ligand:
Ligand ZN 1 x ZN
No modified residues

Experiments and Validation Details

wwPDB Validation report is not available for this entry.
X-ray source: SSRF BEAMLINE BL17U1
Spacegroup: P41212
Unit cell:
a: 62.182Å b: 62.182Å c: 117.28Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.207 0.206 0.226
Expression system: Escherichia coli BL21(DE3)

Quick links

Citations

5 review citations

Bacterial zinc uptake regulator proteins and their regulons.
Mikhaylina et al. (2018)
4 more

2 mentions without citation

Allosteric histidine switch for regulation of intracellular zinc(II) fluctuation.
Zhu et al. (2017)
1 more