5ypr

X-ray diffraction
2.35Å resolution

Crystal Structure of PSD-95 SH3-GK domain in complex with a synthesized inhibitor

Released:

Function and Biology Details

Structure analysis Details

Assembly composition:
hetero dimer (preferred)
PDBe Complex ID:
PDB-CPX-151884 (preferred)
Entry contents:
2 distinct polypeptide molecules
Macromolecules (2 distinct):
Disks large homolog 4 Chain: A
Molecule details ›
Chain: A
Length: 318 amino acids
Theoretical weight: 36.84 KDa
Source organism: Rattus norvegicus
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: P31016 (Residues: 426-721; Coverage: 41%)
Gene names: Dlg4, Dlgh4, Psd95
Sequence domains:
Structure domains:
Synthesized GK inhibitor Chain: B
Molecule details ›
Chain: B
Length: 16 amino acids
Theoretical weight: 2.06 KDa
Source organism: synthetic construct
Expression system: Not provided

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: SSRF BEAMLINE BL19U1
Spacegroup: C2
Unit cell:
a: 119.028Å b: 45.743Å c: 86.358Å
α: 90° β: 103.22° γ: 90°
R-values:
R R work R free
0.224 0.222 0.264
Expression systems:
  • Escherichia coli BL21(DE3)
  • Not provided