Function and Biology Details
Reactions catalysed:
S-adenosyl-L-methionine + a 5'-(N(7)-methyl 5'-triphosphoguanosine)-(ribonucleotide)-[mRNA] = S-adenosyl-L-homocysteine + a 5'-(N(7)-methyl 5'-triphosphoguanosine)-(2'-O-methyl-ribonucleotide)-[mRNA]
Thiol-dependent hydrolysis of ester, thioester, amide, peptide and isopeptide bonds formed by the C-terminal Gly of ubiquitin (a 76-residue protein attached to proteins as an intracellular targeting signal).
ATP + H(2)O = ADP + phosphate
Biochemical function:
- not assigned
Biological process:
- not assigned
Cellular component:
- not assigned
Sequence domains:
- NendoU domain, nidovirus
- Endoribonuclease EndoU-like
- Nonstructural protein 15, middle domain, alpha/betacoronavirus
- Non-structural protein NSP15, middle domain superfamily
- Nonstructural protein 15, middle domain, coronavirus
- Arterivirus Nsp11 N-terminal/Coronavirus NSP15 middle domain
- Nonstructural protein 15, N-terminal domain, alpha/beta-coronavirus
- Coronavirus replicase NSP15, N-terminal oligomerization
2 more domains
Structure analysis Details
Assembly composition:
homo hexamer (preferred)
Assembly name:
Nsp15 (preferred)
PDBe Complex ID:
PDB-CPX-102736 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Nsp15
Molecule details ›
Chains: A, B
Length: 343 amino acids
Theoretical weight: 39.27 KDa
Source organism: Middle East respiratory syndrome-related coronavirus
Expression system: Escherichia coli
UniProt:
Sequence domains:
Length: 343 amino acids
Theoretical weight: 39.27 KDa
Source organism: Middle East respiratory syndrome-related coronavirus
Expression system: Escherichia coli
UniProt:
- Canonical:
A0A0U2GPI9 (Residues: 6433-6775; Coverage: 5%)
Sequence domains:
- Coronavirus replicase NSP15, N-terminal oligomerisation
- Coronavirus replicase NSP15, middle domain
- Coronavirus replicase NSP15, uridylate-specific endoribonuclease
