› 5z2s

X-ray diffraction
1.5Å resolution

Crystal structure of DUX4-HD2 domain

Released:
DOI: 10.2210/pdb5z2s/pdb
PDB entry 5z2s coloured by chain, front view.
PDB entry 5z2s coloured by chain, side view.
PDB entry 5z2s coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Structural basis of DUX4/IGH-driven transactivation.
Dong X, Zhang W, Wu H, Huang J, Zhang M, Wang P, Zhang H, Chen Z, Chen SJ, Meng G
Leukemia 32 1466-1476 (2018)
PMID: 29572508

Function and Biology Details

Biochemical function:
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-193689 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Double homeobox protein 4 Chain: A
Molecule details ›
Chain: A
Length: 55 amino acids
Theoretical weight: 6.29 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: Q9UBX2 (Residues: 100-150; Coverage: 12%)
Gene names: DUX10, DUX4
Sequence domains: Homeodomain
Structure domains: Homeodomain-like

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: SSRF BEAMLINE BL17U1
Spacegroup: P212121
Unit cell:
a: 25.15Å b: 25.39Å c: 72.57Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.19 0.189 0.215
Expression system: Escherichia coli

Quick links

Citations

4 review citations

Pathomechanisms and biomarkers in facioscapulohumeral muscular dystrophy: roles of DUX4 and PAX7.
Banerji et al. (2021)
3 more

3 mentions without citation

Structural basis of DUX4/IGH-driven transactivation.
Dong et al. (2018)
2 more