Function and Biology Details
Reactions catalysed:
ATP + H(2)O = ADP + phosphate
S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine
Peptidylproline (omega=180) = peptidylproline (omega=0)
Biochemical function:
Biological process:
Cellular component:
Structure analysis Details
Assembly composition:
hetero 57-mer (preferred)
Assembly name:
Retention and splicing complex and RNA (preferred)
PDBe Complex ID:
PDB-CPX-293065 (preferred)
Entry contents:
43 distinct polypeptide molecules
4 distinct RNA molecules
4 distinct RNA molecules
Macromolecules (47 distinct):
Pre-mRNA-processing-splicing factor 8
Molecule details ›
Chain: A
Length: 2335 amino acids
Theoretical weight: 273.97 KDa
Source organism: Homo sapiens
UniProt:
Sequence domains:
Length: 2335 amino acids
Theoretical weight: 273.97 KDa
Source organism: Homo sapiens
UniProt:
- Canonical:
Q6P2Q9 (Residues: 1-2335; Coverage: 100%)
Sequence domains:
116 kDa U5 small nuclear ribonucleoprotein component
Molecule details ›
Chain: C
Length: 972 amino acids
Theoretical weight: 109.56 KDa
Source organism: Homo sapiens
UniProt:
Sequence domains:
Length: 972 amino acids
Theoretical weight: 109.56 KDa
Source organism: Homo sapiens
UniProt:
- Canonical: Q15029 (Residues: 1-972; Coverage: 100%)
Sequence domains:
U5 small nuclear ribonucleoprotein 200 kDa helicase
U5 small nuclear ribonucleoprotein 40 kDa protein
Small nuclear ribonucleoprotein Sm D3
Small nuclear ribonucleoprotein-associated proteins B and B'
Small nuclear ribonucleoprotein Sm D1
Small nuclear ribonucleoprotein Sm D2
Small nuclear ribonucleoprotein F
Small nuclear ribonucleoprotein E
Small nuclear ribonucleoprotein G
U2 small nuclear ribonucleoprotein A'
U2 small nuclear ribonucleoprotein B''
Splicing factor 3A subunit 3
Splicing factor 3A subunit 1
Splicing factor 3A subunit 2
Splicing factor 3B subunit 1
Splicing factor 3B subunit 2
Splicing factor 3B subunit 3
Splicing factor 3B subunit 4
Splicing factor 3B subunit 6
PHD finger-like domain-containing protein 5A
Splicing factor 3B subunit 5
Crooked neck-like protein 1
Cell division cycle 5-like protein
Pre-mRNA-processing factor 19
Pre-mRNA-splicing factor SPF27
Pre-mRNA-splicing factor SYF1
RNA helicase aquarius
Protein BUD31 homolog
Pre-mRNA-splicing factor RBM22
Spliceosome-associated protein CWC15 homolog
Peptidyl-prolyl cis-trans isomerase-like 1
Pleiotropic regulator 1
Serine/arginine repetitive matrix protein 2
Pre-mRNA-splicing factor CWC22 homolog
Pre-mRNA-processing factor 17
Smad nuclear-interacting protein 1
RNA-binding motif protein, X-linked 2
BUD13 homolog
Pre-mRNA-splicing factor ATP-dependent RNA helicase DHX16
Peptidyl-prolyl cis-trans isomerase E
