5z7g

X-ray diffraction
2.3Å resolution

Crystal structure of TAX1BP1 SKICH region in complex with NAP1

Released:
Source organism: Homo sapiens
Primary publication:
Mechanistic insights into the interactions of NAP1 with the SKICH domains of NDP52 and TAX1BP1.
Proc Natl Acad Sci U S A 115 E11651-E11660 (2018)
PMID: 30459273

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domain:

Structure analysis Details

Assembly composition:
hetero tetramer (preferred)
PDBe Complex ID:
PDB-CPX-183214 (preferred)
Entry contents:
2 distinct polypeptide molecules
Macromolecules (2 distinct):
Tax1-binding protein 1 Chains: A, B
Molecule details ›
Chains: A, B
Length: 121 amino acids
Theoretical weight: 14.14 KDa
Source organism: Homo sapiens
Expression system: Enterobacteria phage L1
UniProt:
  • Canonical: Q86VP1 (Residues: 1-121; Coverage: 15%)
Gene names: PRO0105, T6BP, TAX1BP1
Sequence domains: SKICH domain
Structure domains: Immunoglobulin-like
5-azacytidine-induced protein 2 Chains: C, D
Molecule details ›
Chains: C, D
Length: 43 amino acids
Theoretical weight: 5.06 KDa
Source organism: Homo sapiens
Expression system: Enterobacteria phage L1
UniProt:
  • Canonical: Q9H6S1 (Residues: 33-75; Coverage: 11%)
Gene names: AZI2, NAP1, TBKBP2

Ligands and Environments

1 bound ligand:
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: SSRF BEAMLINE BL17U1
Spacegroup: P63
Unit cell:
a: 118.487Å b: 118.487Å c: 64.344Å
α: 90° β: 90° γ: 120°
R-values:
R R work R free
0.189 0.187 0.233
Expression system: Enterobacteria phage L1