› 5z8x

X-ray diffraction
3.15Å resolution

Crystal structure of human LRRTM2

Released:
DOI: 10.2210/pdb5z8x/pdb
PDB entry 5z8x coloured by chain, front view.
PDB entry 5z8x coloured by chain, side view.
PDB entry 5z8x coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Structural insights into modulation and selectivity of transsynaptic neurexin-LRRTM interaction.
Yamagata A, Goto-Ito S, Sato Y, Shiroshima T, Maeda A, Watanabe M, Saitoh T, Maenaka K, Terada T, Yoshida T, Uemura T, Fukai S
Nat Commun 9 3964 (2018)
PMID: 30262834

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-128889 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Leucine-rich repeat transmembrane neuronal protein 2 Chains: A, B, C, D
Molecule details ›
Chains: A, B, C, D
Length: 346 amino acids
Theoretical weight: 39.86 KDa
Source organism: Homo sapiens
Expression system: Homo sapiens
UniProt:
  • Canonical: O43300 (Residues: 34-373; Coverage: 70%)
Gene names: KIAA0416, LRRN2, LRRTM2
Sequence domains: Leucine rich repeat
Structure domains: Ribonuclease Inhibitor

Ligands and Environments

1 bound ligand:
Ligand NAG 8 x NAG
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: SPRING-8 BEAMLINE BL41XU
Spacegroup: C2221
Unit cell:
a: 90.691Å b: 240.959Å c: 259.434Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.204 0.203 0.231
Expression system: Homo sapiens

Quick links

Citations

5 review citations

Neurexins: molecular codes for shaping neuronal synapses.
Gomez et al. (2021)
4 more