› 5zgl

X-ray diffraction
0.95Å resolution

hnRNP A1 segment GGGYGGS (residues 234-240)

Released:
DOI: 10.2210/pdb5zgl/pdb
PDB entry 5zgl coloured by chain, front view.
PDB entry 5zgl coloured by chain, side view.
PDB entry 5zgl coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Structural basis for reversible amyloids of hnRNPA1 elucidates their role in stress granule assembly.
Gui X, Luo F, Li Y, Zhou H, Qin Z, Liu Z, Gu J, Xie M, Zhao K, Dai B, Shin WS, He J, He L, Jiang L, Zhao M, Sun B, Li X, Liu C, Li D
Nat Commun 10 2006 (2019)
PMID: 31043593

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-140720 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Heterogeneous nuclear ribonucleoprotein A1, N-terminally processed Chains: A, B
Molecule details ›
Chains: A, B
Length: 7 amino acids
Theoretical weight: 554 Da
Source organism: Homo sapiens
Expression system: Not provided
UniProt:
  • Canonical: P09651 (Residues: 234-240; Coverage: 2%)
Gene names: HNRNPA1, HNRPA1

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: SSRF BEAMLINE BL17U1
Spacegroup: P21
Unit cell:
a: 11.957Å b: 10.141Å c: 21.372Å
α: 90° β: 100.11° γ: 90°
R-values:
R R work R free
0.102 0.1 0.121
Expression system: Not provided

Quick links

Citations

34 review citations

Liquid-liquid phase separation in biology: mechanisms, physiological functions and human diseases.
Zhang et al. (2020)
33 more

2 mentions without citation

hnRNP A/B Proteins: An Encyclopedic Assessment of Their Roles in Homeostasis and Disease.
Thibault et al. (2021)
1 more