› 5zho

X-ray diffraction
1.4Å resolution

Human group C rotavirus VP8*s recognize type A histo-blood group antigens as ligands

Released:
DOI: 10.2210/pdb5zho/pdb
PDB entry 5zho coloured by chain, front view.
PDB entry 5zho coloured by chain, side view.
PDB entry 5zho coloured by chain, top view.
Source organism: Human rotavirus C/Bristol
Primary publication:
Human Group C Rotavirus VP8*s Recognize Type A Histo-Blood Group Antigens as Ligands.
Sun X, Wang L, Qi J, Li D, Wang M, Cong X, Peng R, Chai W, Zhang Q, Wang H, Wen H, Gao GF, Tan M, Duan Z
J Virol 92 (2018)
PMID: 29593033

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
Cellular component:
Sequence domain:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-182627 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecules (2 distinct):
Outer capsid protein VP8* Chain: A
Molecule details ›
Chain: A
Length: 162 amino acids
Theoretical weight: 18.74 KDa
Source organism: Human rotavirus C/Bristol
Expression system: Escherichia coli K-12
UniProt:
  • Canonical: Q82040 (Residues: 64-224; Coverage: 22%)
Sequence domains: Outer Capsid protein VP4 (Hemagglutinin) Concanavalin-like domain

Ligands and Environments

Carbohydrate polymer : NEW Components: GLA, FUC, A2G
Carbohydrate polymer
No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: SSRF BEAMLINE BL19U1
Spacegroup: P212121
Unit cell:
a: 37.985Å b: 39.821Å c: 119.814Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.143 0.141 0.174
Expression system: Escherichia coli K-12

Quick links

Citations

2 review citations

Glycan Microarrays as Chemical Tools for Identifying Glycan Recognition by Immune Proteins.
Gao et al. (2019)
1 more

4 mentions without citation

Structural Basis of Glycan Recognition of Rotavirus.
Sun et al. (2021)
3 more