› 5zo7

X-ray diffraction
2.6Å resolution

Kinesin spindle protein Eg5 in complex with STLC-type inhibitor PVEI0138

Released:
DOI: 10.2210/pdb5zo7/pdb
PDB entry 5zo7 coloured by chain, front view.
PDB entry 5zo7 coloured by chain, side view.
PDB entry 5zo7 coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Structural and Thermodynamic Basis of the Enhanced Interaction between Kinesin Spindle Protein Eg5 and STLC-type Inhibitors.
Yokoyama H, Sawada JI, Sato K, Ogo N, Kamei N, Ishikawa Y, Hara K, Asai A, Hashimoto H
ACS Omega 3 12284-12294 (2018)
PMID: 31459302

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-156612 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Kinesin-like protein KIF11 Chains: A, B
Molecule details ›
Chains: A, B
Length: 367 amino acids
Theoretical weight: 41.3 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: P52732 (Residues: 17-369; Coverage: 33%)
Gene names: EG5, KIF11, KNSL1, TRIP5
Sequence domains: Kinesin motor domain
Structure domains: Kinesin motor domain

Ligands and Environments

4 bound ligands:
Ligand ADP 2 x ADP
Ligand MG 2 x MG
Ligand 5C5 2 x 5C5
Ligand SO4 2 x SO4
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: SPRING-8 BEAMLINE BL26B1
Spacegroup: C2
Unit cell:
a: 158.347Å b: 50.58Å c: 93.689Å
α: 90° β: 102.2° γ: 90°
R-values:
R R work R free
0.231 0.225 0.283
Expression system: Escherichia coli BL21(DE3)

Quick links

Citations

2 citation in other articles

RAB11A and RAB11B control mitotic spindle function in intestinal epithelial progenitor cells.
Joseph et al. (2023)
1 more