Function and Biology Details
Reactions catalysed:
S-adenosyl-L-methionine + a 5'-(5'-triphosphoguanosine)-[mRNA] = S-adenosyl-L-homocysteine + a 5'-(N(7)-methyl 5'-triphosphoguanosine)-[mRNA]
S-adenosyl-L-methionine + a 5'-(N(7)-methyl 5'-triphosphoguanosine)-(ribonucleotide)-[mRNA] = S-adenosyl-L-homocysteine + a 5'-(N(7)-methyl 5'-triphosphoguanosine)-(2'-O-methyl-ribonucleotide)-[mRNA]
Nucleoside triphosphate + RNA(n) = diphosphate + RNA(n+1)
Selective hydrolysis of -Xaa-Xaa-|-Yaa- bonds in which each of the Xaa can be either Arg or Lys and Yaa can be either Ser or Ala.
NTP + H(2)O = NDP + phosphate
ATP + H(2)O = ADP + phosphate
Biochemical function:
Biological process:
- not assigned
Cellular component:
Structure analysis Details
Assembly composition:
hetero pentamer (preferred)
Assembly name:
Serine protease NS3 and peptide (preferred)
PDBe Complex ID:
PDB-CPX-166380 (preferred)
Entry contents:
3 distinct polypeptide molecules
Macromolecules (3 distinct):
Serine protease subunit NS2B
Molecule details ›
Chains: A, C, E, G
Length: 53 amino acids
Theoretical weight: 5.87 KDa
Source organism: Zika virus
Expression system: Escherichia coli
UniProt:
Length: 53 amino acids
Theoretical weight: 5.87 KDa
Source organism: Zika virus
Expression system: Escherichia coli
UniProt:
- Canonical:
Q32ZE1 (Residues: 1414-1464; Coverage: 2%)
Serine protease NS3
Molecule details ›
Chains: B, D, F, H
Length: 178 amino acids
Theoretical weight: 19.04 KDa
Source organism: Zika virus
Expression system: Escherichia coli
UniProt:
Structure domains:
Length: 178 amino acids
Theoretical weight: 19.04 KDa
Source organism: Zika virus
Expression system: Escherichia coli
UniProt:
- Canonical: Q32ZE1 (Residues: 1499-1675; Coverage: 5%)
Structure domains:
Ligands and Environments
No bound ligands
No modified residues
Experiments and Validation Details
X-ray source:
SLS BEAMLINE X06DA
Spacegroup:
P212121
Expression systems:
- Escherichia coli
- Not provided
