› 5zpw

X-ray diffraction
2.2Å resolution

Generation of a long-acting fusion inhibitor against HIV-1

Released:
DOI: 10.2210/pdb5zpw/pdb
PDB entry 5zpw coloured by chain, front view.
PDB entry 5zpw coloured by chain, side view.
PDB entry 5zpw coloured by chain, top view.
Source organisms:
Primary publication:
Generation of a long-acting fusion inhibitor against HIV-1.
Guo Y, Zhou PP, Zhang SY, Fan XW, Dou YW, Shi XL
Medchemcomm 9 1226-1231 (2018)
PMID: 30109011

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned

Structure analysis Details

Assembly composition:
hetero hexamer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-103729 (preferred)
Entry contents:
2 distinct polypeptide molecules
Macromolecules (2 distinct):
Envelope glycoprotein Chains: A, C, E
Molecule details ›
Chains: A, C, E
Length: 35 amino acids
Theoretical weight: 4.13 KDa
Source organism: Human immunodeficiency virus 1
Expression system: Not provided
UniProt:
  • Canonical: A0A1S6KGE5 (Residues: 23-57; Coverage: 20%)
MET-THR-TRP-GLU-GLU-TRP-ASP-MK8-LYS-ILE-GLU-MK8-TYR-THR-MK8-LYS-ILE-GLU-MK8-LEU-ILE-LYS-LYS-SER Chains: B, D, F
Molecule details ›
Chains: B, D, F
Length: 24 amino acids
Theoretical weight: 3.08 KDa
Source organism: synthetic construct
Expression system: Not provided

Ligands and Environments

No bound ligands
1 modified residue:
Ligand MK8 12 x MK8

Experiments and Validation Details

Entry percentile scores
X-ray source: SSRF BEAMLINE BL17U1
Spacegroup: I4
Unit cell:
a: 84.737Å b: 84.737Å c: 66.144Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.241 0.24 0.263
Expression system: Not provided

Quick links

Citations

1 citations in other articles

Systematic Evaluation of Fluorination as Modification for Peptide-Based Fusion Inhibitors against HIV-1 Infection.
Huhmann et al. (2021)

1 mention without citation

Generation of a long-acting fusion inhibitor against HIV-1.
Guo et al. (2018)