› 5ztf

X-ray diffraction
3.45Å resolution

Function and Biology Details

Reaction catalysed: 
ATP + H(2)O + Ca(2+)(Side 1) = ADP + phosphate + Ca(2+)(Side 2)
Biochemical function:
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-147779 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Sarcoplasmic/endoplasmic reticulum calcium ATPase 2 Chain: A
Molecule details ›
Chain: A
Length: 1070 amino acids
Theoretical weight: 117.76 KDa
Source organism: Homo sapiens
Expression system: Homo sapiens
UniProt:
  • Canonical: P16615 (Residues: 1-1042; Coverage: 100%)
Gene names: ATP2A2, ATP2B
Sequence domains:

Ligands and Environments

3 bound ligands:
Ligand ACP 1 x ACP
Ligand MG 1 x MG
Ligand CA 2 x CA
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: SPRING-8 BEAMLINE BL32XU
Spacegroup: P21212
Unit cell:
a: 165.079Å b: 84.053Å c: 118.832Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.249 0.246 0.308
Expression system: Homo sapiens

Quick links

Citations

8 review citations

Targeting oncogenic Notch signaling with SERCA inhibitors.
Pagliaro et al. (2021)
7 more

4 mentions without citation

Linking Biochemical and Structural States of SERCA: Achievements, Challenges, and New Opportunities.
Aguayo-Ortiz et al. (2020)
3 more