5zyt

X-ray diffraction
2.7Å resolution

Crystal structure of human MGME1 with 3' overhang double strand DNA3

Released:
Source organisms:
Primary publication:
Structural insights into DNA degradation by human mitochondrial nuclease MGME1.
Nucleic Acids Res 46 11075-11088 (2018)
PMID: 30247721

Function and Biology Details

Structure analysis Details

Assembly composition:
hetero dimer (preferred)
PDBe Complex ID:
PDB-CPX-119537 (preferred)
Entry contents:
1 distinct polypeptide molecule
1 distinct DNA molecule
Macromolecules (2 distinct):
Mitochondrial genome maintenance exonuclease 1 Chains: A, B, C, D
Molecule details ›
Chains: A, B, C, D
Length: 324 amino acids
Theoretical weight: 37.05 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: Q9BQP7 (Residues: 21-344; Coverage: 94%)
Gene names: C20orf72, DDK1, MGME1
Sequence domains: PD-(D/E)XK nuclease superfamily
DNA (5'-D(P*CP*TP*TP*CP*TP*TP*CP*C)-3') Chains: E, F, G, H
Molecule details ›
Chains: E, F, G, H
Length: 18 nucleotides
Theoretical weight: 5.4 KDa
Source organism: unidentified
Expression system: Not provided

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: SSRF BEAMLINE BL19U1
Spacegroup: C2
Unit cell:
a: 146.497Å b: 77.489Å c: 164.714Å
α: 90° β: 112.4° γ: 90°
R-values:
R R work R free
0.252 0.25 0.296
Expression systems:
  • Escherichia coli BL21(DE3)
  • Not provided