› 5zz3

X-ray diffraction
3Å resolution

Crystal structure of intracellular B30.2 domain of BTN3A3

Released:
DOI: 10.2210/pdb5zz3/pdb
PDB entry 5zz3 coloured by chain, front view.
PDB entry 5zz3 coloured by chain, side view.
PDB entry 5zz3 coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
A Structural Change in Butyrophilin upon Phosphoantigen Binding Underlies Phosphoantigen-Mediated Vγ9Vδ2 T Cell Activation.
Yang Y, Li L, Yuan L, Zhou X, Duan J, Xiao H, Cai N, Han S, Ma X, Liu W, Chen CC, Wang L, Li X, Chen J, Kang N, Chen J, Shen Z, Malwal SR, Liu W, Shi Y, Oldfield E, Guo RT, Zhang Y
Immunity 50 1043-1053.e5 (2019)
PMID: 30902636

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-126300 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Butyrophilin subfamily 3 member A3 Chain: A
Molecule details ›
Chain: A
Length: 290 amino acids
Theoretical weight: 32.56 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: O00478 (Residues: 328-584; Coverage: 46%)
Gene names: BTF3, BTN3A3
Sequence domains:
Structure domains: Jelly Rolls

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: SSRF BEAMLINE BL19U1
Spacegroup: P43212
Unit cell:
a: 50.308Å b: 50.308Å c: 261.093Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.199 0.195 0.275
Expression system: Escherichia coli BL21(DE3)

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Citations

26 review citations

Cancer immunotherapy with γδ T cells: many paths ahead of us.
Kabelitz et al. (2020)
25 more