› 6a70

Electron Microscopy
3.6Å resolution

Structure of the human PKD1/PKD2 complex

Released:
DOI: 10.2210/pdb6a70/pdb
PDB entry 6a70 coloured by chain, front view.
PDB entry 6a70 coloured by chain, side view.
PDB entry 6a70 coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Structure of the human PKD1-PKD2 complex.
Su Q, Hu F, Ge X, Lei J, Yu S, Wang T, Zhou Q, Mei C, Shi Y
Science 361 (2018)
PMID: 30093605
Related structures: EMD-6991

Function and Biology Details

Biochemical function:
Biological process:
  • not assigned
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
hetero tetramer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-161356 (preferred)
Entry contents:
2 distinct polypeptide molecules
Macromolecules (2 distinct):
Polycystin-2 Chains: A, F, G
Molecule details ›
Chains: A, F, G
Length: 577 amino acids
Theoretical weight: 66.62 KDa
Source organism: Homo sapiens
Expression system: Homo sapiens
UniProt:
  • Canonical: Q13563 (Residues: 185-723; Coverage: 56%)
Gene names: PKD2, TRPP2
Sequence domains:
Polycystin-1 Chain: B
Molecule details ›
Chain: B
Length: 1153 amino acids
Theoretical weight: 127.02 KDa
Source organism: Homo sapiens
Expression system: Homo sapiens
UniProt:
  • Canonical: P98161 (Residues: 3049-4169; Coverage: 26%)
Gene name: PKD1
Sequence domains:

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
Resolution: 3.6Å
Relevant EMDB volumes: EMD-6991
Expression system: Homo sapiens

Quick links

Citations

41 review citations

The glomerular filtration barrier: a structural target for novel kidney therapies.
Daehn et al. (2021)
40 more

13 mentions without citation

Polycystins as components of large multiprotein complexes of polycystin interactors.
Hardy et al. (2020)
12 more