› 6ac0

X-ray diffraction
1.45Å resolution

Crystal structure of TRADD death domain GlcNAcylated by EPEC effector NleB

Released:
DOI: 10.2210/pdb6ac0/pdb
PDB entry 6ac0 coloured by chain, front view.
PDB entry 6ac0 coloured by chain, side view.
PDB entry 6ac0 coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Structural and Functional Insights into Host Death Domains Inactivation by the Bacterial Arginine GlcNAcyltransferase Effector.
Ding J, Pan X, Du L, Yao Q, Xue J, Yao H, Wang DC, Li S, Shao F
Mol Cell 74 922-935.e6 (2019)
PMID: 30979585

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-172342 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Tumor necrosis factor receptor type 1-associated DEATH domain protein Chain: A
Molecule details ›
Chain: A
Length: 118 amino acids
Theoretical weight: 13.33 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: Q15628 (Residues: 195-312; Coverage: 38%)
Gene name: TRADD
Sequence domains: Death domain

Ligands and Environments

1 bound ligand:
Ligand NAG 1 x NAG
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: SSRF BEAMLINE BL17U
Spacegroup: P41212
Unit cell:
a: 28.6Å b: 28.6Å c: 264.72Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.186 0.184 0.224
Expression system: Escherichia coli BL21(DE3)

Quick links

Citations

7 review citations

Type III Secretion Effectors with Arginine N-Glycosyltransferase Activity.
Araujo-Garrido et al. (2020)
6 more

1 mention without citation

Modernized uniform representation of carbohydrate molecules in the Protein Data Bank.
Shao et al. (2021)