› 6aef

X-ray diffraction
2.16Å resolution

Function and Biology Details

Reaction catalysed: 
Palmitoyl-CoA + 2-O-sulfo-alpha,alpha-trehalose = 2-O-sulfo-2'-palmitoyl-alpha,alpha-trehalose + CoA
Biochemical function:
Biological process:
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
homo dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-235858 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Trehalose-2-sulfate acyltransferase PapA2 Chains: A, B
Molecule details ›
Chains: A, B
Length: 468 amino acids
Theoretical weight: 52.18 KDa
Source organism: Mycobacterium tuberculosis H37Rv
Expression system: Escherichia coli
UniProt:
  • Canonical: P9WIK7 (Residues: 2-468; Coverage: 100%)
Gene names: Rv3820c, papA2
Sequence domains: Condensation domain

Ligands and Environments

3 bound ligands:
Ligand ZN 2 x ZN
Ligand ACT 1 x ACT
Ligand TRS 1 x TRS
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: ESRF BEAMLINE BM14
Spacegroup: P212121
Unit cell:
a: 74.707Å b: 100.668Å c: 128.927Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.2 0.198 0.232
Expression system: Escherichia coli

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Citations

3 citation in other articles

Systematic evaluation of computational tools to predict the effects of mutations on protein stability in the absence of experimental structures.
Pan et al. (2022)
2 more