› 6aex

X-ray diffraction
2.39Å resolution

Crystal structure of unoccupied murine uPAR

Released:
DOI: 10.2210/pdb6aex/pdb
PDB entry 6aex coloured by chain, front view.
PDB entry 6aex coloured by chain, side view.
PDB entry 6aex coloured by chain, top view.
Source organism: Mus musculus
Primary publication:
Crystal structure of the unoccupied murine urokinase-type plasminogen activator receptor (uPAR) reveals a tightly packed DII-DIII unit.
Liu M, Lin L, Høyer-Hansen G, Ploug M, Li H, Jiang L, Yuan C, Li J, Huang M
FEBS Lett 593 1236-1247 (2019)
PMID: 31044429

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-152924 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Urokinase plasminogen activator surface receptor Chain: U
Molecule details ›
Chain: U
Length: 277 amino acids
Theoretical weight: 30.17 KDa
Source organism: Mus musculus
Expression system: Drosophila melanogaster
UniProt:
  • Canonical: P35456 (Residues: 24-300; Coverage: 91%)
Gene name: Plaur
Sequence domains: u-PAR/Ly-6 domain

Ligands and Environments

1 bound ligand:
Ligand NAG 1 x NAG
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: NSLS BEAMLINE X29A
Spacegroup: P41212
Unit cell:
a: 83.82Å b: 83.82Å c: 81.398Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.198 0.195 0.244
Expression system: Drosophila melanogaster

Quick links

Citations

3 review citations

The Urokinase Receptor: A Multifunctional Receptor in Cancer Cell Biology. Therapeutic Implications.
Li Santi et al. (2021)
2 more

1 mention without citation

Identification of a Novel Theranostic Signature of Metabolic and Immune-Inflammatory Dysregulation in Myocardial Infarction, and the Potential Therapeutic Properties of Ovatodiolide, a Diterpenoid Derivative.
Wu et al. (2022)