6ahy

X-ray diffraction
2.8Å resolution

Wnt signaling complex

Released:
Source organisms:
Primary publication:
Crystal structure of a mammalian Wnt-frizzled complex.
Nat Struct Mol Biol 26 372-379 (2019)
PMID: 31036956

Function and Biology Details

Structure analysis Details

Assembly composition:
hetero dimer (preferred)
PDBe Complex ID:
PDB-CPX-157528 (preferred)
Entry contents:
2 distinct polypeptide molecules
Macromolecules (3 distinct):
Frizzled-8 Chains: A, C, E
Molecule details ›
Chains: A, C, E
Length: 141 amino acids
Theoretical weight: 16.24 KDa
Source organism: Mus musculus
Expression system: Homo sapiens
UniProt:
  • Canonical: Q61091 (Residues: 28-159; Coverage: 20%)
Gene name: Fzd8
Sequence domains: Fz domain
Structure domains: Frizzled cysteine-rich domain
Proto-oncogene Wnt-3 Chains: B, D, F
Molecule details ›
Chains: B, D, F
Length: 319 amino acids
Theoretical weight: 36.25 KDa
Source organism: Homo sapiens
Expression system: Homo sapiens
UniProt:
  • Canonical: P56703 (Residues: 42-355; Coverage: 94%)
Gene names: INT4, WNT3
Sequence domains: wnt family

Ligands and Environments

Carbohydrate polymer : NEW Components: NAG
3 bound ligands:
1 modified residue:

Experiments and Validation Details

Entry percentile scores
X-ray source: SPRING-8 BEAMLINE BL44XU
Spacegroup: I212121
Unit cell:
a: 120.073Å b: 141.611Å c: 260.692Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.207 0.205 0.244
Expression system: Homo sapiens