› 6aj2

Electron Microscopy
4Å resolution

The structure of ICAM-5 triggered Enterovirus D68 virus A-particle

Released:
DOI: 10.2210/pdb6aj2/pdb
PDB entry 6aj2 coloured by chain, front view.
PDB entry 6aj2 coloured by chain, side view.
PDB entry 6aj2 coloured by chain, top view.
Source organism: enterovirus D68
Primary publication:
Atomic structures of enterovirus D68 in complex with two monoclonal antibodies define distinct mechanisms of viral neutralization.
Zheng Q, Zhu R, Xu L, He M, Yan X, Liu D, Yin Z, Wu Y, Li Y, Yang L, Hou W, Li S, Li Z, Chen Z, Li Z, Yu H, Gu Y, Zhang J, Baker TS, Zhou ZH, Graham BS, Cheng T, Li S, Xia N
Nat Microbiol 4 124-133 (2019)
PMID: 30397341
Related structures: EMD-9631

Function and Biology Details

Reactions catalysed: 
Nucleoside triphosphate + RNA(n) = diphosphate + RNA(n+1)
Selective cleavage of Gln-|-Gly bond in the poliovirus polyprotein. In other picornavirus reactions Glu may be substituted for Gln, and Ser or Thr for Gly.
Selective cleavage of Tyr-|-Gly bond in picornavirus polyprotein.
NTP + H(2)O = NDP + phosphate
Biochemical function:
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
hetero 180-mer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-100747 (preferred)
Entry contents:
3 distinct polypeptide molecules
Macromolecules (3 distinct):
Capsid protein VP1 Chain: A
Molecule details ›
Chain: A
Length: 295 amino acids
Theoretical weight: 32.67 KDa
Source organism: enterovirus D68
UniProt:
  • Canonical: A0A097F8Q2 (Residues: 565-859; Coverage: 14%)
Sequence domains: picornavirus capsid protein
Capsid protein VP2 Chain: B
Molecule details ›
Chain: B
Length: 248 amino acids
Theoretical weight: 27.57 KDa
Source organism: enterovirus D68
UniProt:
  • Canonical: A0A097F8Q2 (Residues: 70-317; Coverage: 11%)
Sequence domains: picornavirus capsid protein
Capsid protein VP3 Chain: C
Molecule details ›
Chain: C
Length: 247 amino acids
Theoretical weight: 27.14 KDa
Source organism: enterovirus D68
UniProt:
  • Canonical: A0A097F8Q2 (Residues: 318-564; Coverage: 11%)
Sequence domains: picornavirus capsid protein
Structure domains: Jelly Rolls

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
Resolution: 4Å
Relevant EMDB volumes: EMD-9631

Quick links

Citations

6 review citations

Current Understanding of Human Enterovirus D68.
Sun et al. (2019)
5 more

3 mentions without citation

Role of the mechanisms for antibody repertoire diversification in monoclonal light chain deposition disorders: when a friend becomes foe.
Del Pozo-Yauner et al. (2023)
2 more