› 6ak2

X-ray diffraction
1.87Å resolution

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
hetero dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-166414 (preferred)
Entry contents:
2 distinct polypeptide molecules
Macromolecules (2 distinct):
Syntenin-1 Chains: A, B
Molecule details ›
Chains: A, B
Length: 81 amino acids
Theoretical weight: 8.84 KDa
Source organism: Rattus norvegicus
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: Q9JI92 (Residues: 113-193; Coverage: 27%)
Gene name: Sdcbp
Sequence domains: PDZ domain
peptide inhibitor KSL-128018 Chains: D, E
Molecule details ›
Chains: D, E
Length: 7 amino acids
Theoretical weight: 904 Da
Source organism: synthetic construct
Expression system: Not provided

Ligands and Environments

No bound ligands
1 modified residue:
Ligand TBG 2 x TBG

Experiments and Validation Details

Entry percentile scores
X-ray source: PAL/PLS BEAMLINE 5C (4A)
Spacegroup: C2
Unit cell:
a: 95.58Å b: 38.396Å c: 56.777Å
α: 90° β: 92.52° γ: 90°
R-values:
R R work R free
0.212 0.209 0.241
Expression systems:
  • Escherichia coli BL21(DE3)
  • Not provided

Quick links

Citations

3 review citations

Targeting PDZ domains as potential treatment for viral infections, neurodegeneration and cancer.
Nardella et al. (2021)
2 more