› 6akk

X-ray diffraction
1.5Å resolution

Crystal structure of the second Coiled-coil domain of SIKE1

Released:
DOI: 10.2210/pdb6akk/pdb
PDB entry 6akk coloured by chain, front view.
PDB entry 6akk coloured by chain, side view.
PDB entry 6akk coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Architecture, substructures, and dynamic assembly of STRIPAK complexes in Hippo signaling.
Tang Y, Chen M, Zhou L, Ma J, Li Y, Zhang H, Shi Z, Xu Q, Zhang X, Gao Z, Zhao Y, Cheng Y, Jiao S, Zhou Z
Cell Discov 5 3 (2019)
PMID: 30622739

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domain:

Structure analysis Details

Assembly composition:
homo tetramer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-189696 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Suppressor of IKBKE 1 Chains: A, B
Molecule details ›
Chains: A, B
Length: 54 amino acids
Theoretical weight: 6.43 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: Q9BRV8 (Residues: 72-121; Coverage: 24%)
Gene names: SIKE, SIKE1

Ligands and Environments

1 bound ligand:
Ligand GOL 1 x GOL
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: SSRF BEAMLINE BL17U1
Spacegroup: C2221
Unit cell:
a: 42.797Å b: 110.871Å c: 46.438Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.248 0.246 0.267
Expression system: Escherichia coli BL21(DE3)

Quick links

Citations

9 review citations

MOB (Mps one Binder) Proteins in the Hippo Pathway and Cancer.
Gundogdu et al. (2019)
8 more

2 mentions without citation

Architecture, substructures, and dynamic assembly of STRIPAK complexes in Hippo signaling.
Tang et al. (2019)
1 more