› 6aly

Solution NMR

Solution structure of yeast Med15 ABD2 residues 277-368

Released:
DOI: 10.2210/pdb6aly/pdb
PDB entry 6aly coloured by chain, ensemble of 20 models, front view.
PDB entry 6aly coloured by chain, ensemble of 20 models, side view.
PDB entry 6aly coloured by chain, ensemble of 20 models, top view.
Source organism: Saccharomyces cerevisiae
Primary publication:
Gcn4-Mediator Specificity Is Mediated by a Large and Dynamic Fuzzy Protein-Protein Complex.
Tuttle LM, Pacheco D, Warfield L, Luo J, Ranish J, Hahn S, Klevit RE
Cell Rep 22 3251-3264 (2018)
PMID: 29562181

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-148682 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Mediator of RNA polymerase II transcription subunit 15 Chain: A
Molecule details ›
Chain: A
Length: 92 amino acids
Theoretical weight: 10.53 KDa
Source organism: Saccharomyces cerevisiae
Expression system: Escherichia coli
UniProt:
  • Canonical: P19659 (Residues: 277-368; Coverage: 9%)
Gene names: ABE1, GAL11, MED15, RAR3, SDS4, SPT13, YOL051W

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
Chemical shift assignment: 71%
Refinement method: simulated annealing
Expression system: Escherichia coli

Quick links

Citations

19 review citations

Advances in targeting 'undruggable' transcription factors with small molecules.
Henley et al. (2021)
18 more

4 mentions without citation

Twenty years of Mediator complex structural studies.
Verger et al. (2019)
3 more