› 6ao4

X-ray diffraction
2.9Å resolution

Crystal structure of the human gasdermin D C-terminal domain

Released:
DOI: 10.2210/pdb6ao4/pdb
PDB entry 6ao4 coloured by chain, front view.
PDB entry 6ao4 coloured by chain, side view.
PDB entry 6ao4 coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Structures of the Gasdermin D C-Terminal Domains Reveal Mechanisms of Autoinhibition.
Liu Z, Wang C, Rathkey JK, Yang J, Dubyak GR, Abbott DW, Xiao TS
Structure 26 778-784.e3 (2018)
PMID: 29576317

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-157625 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Gasdermin-D, C-terminal Chain: A
Molecule details ›
Chain: A
Length: 209 amino acids
Theoretical weight: 22.35 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: P57764 (Residues: 277-484; Coverage: 43%)
Gene names: DFNA5L, FKSG10, GSDMD, GSDMDC1
Sequence domains: Gasdermin PUB domain

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: APS BEAMLINE 22-ID
Spacegroup: P21212
Unit cell:
a: 47.75Å b: 108.54Å c: 45.91Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.236 0.232 0.29
Expression system: Escherichia coli

Quick links

Citations

26 review citations

Caspases in Cell Death, Inflammation, and Pyroptosis.
Kesavardhana et al. (2020)
25 more

3 mentions without citation

Crystal Structures of the Full-Length Murine and Human Gasdermin D Reveal Mechanisms of Autoinhibition, Lipid Binding, and Oligomerization.
Liu et al. (2019)
2 more