› 6ar0

X-ray diffraction
1.08Å resolution

Structure of human SLMAP FHA domain

Released:
DOI: 10.2210/pdb6ar0/pdb
PDB entry 6ar0 coloured by chain, front view.
PDB entry 6ar0 coloured by chain, side view.
PDB entry 6ar0 coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
SAV1 promotes Hippo kinase activation through antagonizing the PP2A phosphatase STRIPAK.
Bae SJ, Ni L, Osinski A, Tomchick DR, Brautigam CA, Luo X
Elife 6 (2017)
PMID: 29063833

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-172140 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Sarcolemmal membrane-associated protein Chain: A
Molecule details ›
Chain: A
Length: 140 amino acids
Theoretical weight: 15.79 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: Q14BN4 (Residues: 1-140; Coverage: 17%)
Gene names: KIAA1601, SLAP, SLMAP, UNQ1847/PRO3577
Sequence domains: FHA domain

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: APS BEAMLINE 19-ID
Spacegroup: P212121
Unit cell:
a: 42.895Å b: 51.217Å c: 56.422Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.164 0.164 0.179
Expression system: Escherichia coli

Quick links

Citations

25 review citations

The Hippo Pathway: Biology and Pathophysiology.
Ma et al. (2019)
24 more

1 mention without citation

SAV1 promotes Hippo kinase activation through antagonizing the PP2A phosphatase STRIPAK.
Bae et al. (2017)