› 6avj

X-ray diffraction
1.9Å resolution

Crystal structure of human Mitochondrial inner NEET protein (MiNT)/CISD3

Released:
DOI: 10.2210/pdb6avj/pdb
PDB entry 6avj coloured by chain, front view.
PDB entry 6avj coloured by chain, side view.
PDB entry 6avj coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Structure of the human monomeric NEET protein MiNT and its role in regulating iron and reactive oxygen species in cancer cells.
Lipper CH, Karmi O, Sohn YS, Darash-Yahana M, Lammert H, Song L, Liu A, Mittler R, Nechushtai R, Onuchic JN, Jennings PA
Proc Natl Acad Sci U S A 115 272-277 (2018)
PMID: 29259115

Function and Biology Details

Biochemical function:
Biological process:
  • not assigned
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-143157 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
CDGSH iron-sulfur domain-containing protein 3, mitochondrial Chains: A, B, C
Molecule details ›
Chains: A, B, C
Length: 92 amino acids
Theoretical weight: 10.22 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: P0C7P0 (Residues: 36-127; Coverage: 72%)
Gene name: CISD3
Sequence domains: Iron-binding zinc finger CDGSH type

Ligands and Environments

1 bound ligand:
Ligand FES 6 x FES
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: RIGAKU MICROMAX-007 HF
Spacegroup: C2
Unit cell:
a: 91.406Å b: 52.25Å c: 78.951Å
α: 90° β: 108.67° γ: 90°
R-values:
R R work R free
0.171 0.169 0.198
Expression system: Escherichia coli

Quick links

Citations

10 review citations

Iron Metabolism in Cancer.
Wang et al. (2018)
9 more

3 mentions without citation

Elucidating the mitochondrial proteome of Toxoplasma gondii reveals the presence of a divergent cytochrome c oxidase.
Seidi et al. (2018)
2 more