› 6axv

X-ray diffraction
2.77Å resolution

Structure of the T58S/T107I/P122A mutant of the HIV-1 capsid protein in complex with PF-3450074 (PF74)

Released:
DOI: 10.2210/pdb6axv/pdb
PDB entry 6axv coloured by chain, front view.
PDB entry 6axv coloured by chain, side view.
PDB entry 6axv coloured by chain, top view.
Source organism: Human immunodeficiency virus 1
Entry authors: Gres AT, Kirby KA, Sarafianos SG

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
homo hexamer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-146190 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Capsid protein p24 Chain: A
Molecule details ›
Chain: A
Length: 231 amino acids
Theoretical weight: 25.6 KDa
Source organism: Human immunodeficiency virus 1
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: P12493 (Residues: 133-363; Coverage: 46%)
Gene name: gag
Sequence domains:

Ligands and Environments

3 bound ligands:
Ligand IOD 5 x IOD
Ligand CL 9 x CL
Ligand 1B0 1 x 1B0
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: ALS BEAMLINE 4.2.2
Spacegroup: P6
Unit cell:
a: 92.998Å b: 92.998Å c: 57.631Å
α: 90° β: 90° γ: 120°
R-values:
R R work R free
0.231 0.228 0.278
Expression system: Escherichia coli BL21(DE3)

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