› 6ayf

Electron Microscopy
3.62Å resolution

TRPML3/ML-SA1 complex at pH 7.4

Released:
DOI: 10.2210/pdb6ayf/pdb
PDB entry 6ayf coloured by chain, front view.
PDB entry 6ayf coloured by chain, side view.
PDB entry 6ayf coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Cryo-EM structures of the human endolysosomal TRPML3 channel in three distinct states.
Zhou X, Li M, Su D, Jia Q, Li H, Li X, Yang J
Nat Struct Mol Biol 24 1146-1154 (2017)
PMID: 29106414
Related structures: EMD-7019

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
homo tetramer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-186207 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Mucolipin-3 Chains: A, B, C, D
Molecule details ›
Chains: A, B, C, D
Length: 558 amino acids
Theoretical weight: 64.63 KDa
Source organism: Homo sapiens
Expression system: Trichoplusia ni
UniProt:
  • Canonical: Q8TDD5 (Residues: 1-553; Coverage: 100%)
Gene name: MCOLN3
Sequence domains:

Ligands and Environments

1 bound ligand:
Ligand NAG 8 x NAG
No modified residues

Experiments and Validation Details

Entry percentile scores
Resolution: 3.62Å
Relevant EMDB volumes: EMD-7019
Expression system: Trichoplusia ni

Quick links

Citations

18 review citations

Membrane protein structural biology in the era of single particle cryo-EM.
Cheng Y. (2018)
17 more

5 mentions without citation

Structural Pharmacology of TRP Channels.
Zhao et al. (2021)
4 more