› 6b25

X-ray diffraction
2.39Å resolution

Crystal structure of human STAC1 Tandem SH3 Domains (288-402)

Released:
DOI: 10.2210/pdb6b25/pdb
PDB entry 6b25 coloured by chain, front view.
PDB entry 6b25 coloured by chain, side view.
PDB entry 6b25 coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Structural insights into binding of STAC proteins to voltage-gated calcium channels.
Wong King Yuen SM, Campiglio M, Tung CC, Flucher BE, Van Petegem F
Proc Natl Acad Sci U S A 114 E9520-E9528 (2017)
PMID: 29078335

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-189200 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
SH3 and cysteine-rich domain-containing protein Chain: A
Molecule details ›
Chain: A
Length: 118 amino acids
Theoretical weight: 13.68 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: Q99469 (Residues: 288-402; Coverage: 29%)
Gene names: STAC, STAC1
Sequence domains:
Structure domains: SH3 Domains

Ligands and Environments

1 bound ligand:
Ligand EPE 1 x EPE
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: SSRL BEAMLINE BL9-2
Spacegroup: P212121
Unit cell:
a: 28.958Å b: 36.727Å c: 113.001Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.205 0.203 0.259
Expression system: Escherichia coli

Quick links

Citations

9 review citations

Skeletal muscle CaV1.1 channelopathies.
Flucher BE. (2020)
8 more

2 mentions without citation

Structural insights into binding of STAC proteins to voltage-gated calcium channels.
Wong King Yuen et al. (2017)
1 more