› 6b28

X-ray diffraction
2.55Å resolution

Crystal structure of human STAC2 Tandem SH3 Domains Q347I (296-411)

Released:
DOI: 10.2210/pdb6b28/pdb
PDB entry 6b28 coloured by chain, front view.
PDB entry 6b28 coloured by chain, side view.
PDB entry 6b28 coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Structural insights into binding of STAC proteins to voltage-gated calcium channels.
Wong King Yuen SM, Campiglio M, Tung CC, Flucher BE, Van Petegem F
Proc Natl Acad Sci U S A 114 E9520-E9528 (2017)
PMID: 29078335

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-180578 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
SH3 and cysteine-rich domain-containing protein 2 Chain: A
Molecule details ›
Chain: A
Length: 120 amino acids
Theoretical weight: 13.46 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: Q6ZMT1 (Residues: 296-411; Coverage: 28%)
Gene name: STAC2
Sequence domains:
Structure domains: SH3 Domains

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: RIGAKU MICROMAX-007 HF
Spacegroup: P212121
Unit cell:
a: 35.383Å b: 49.707Å c: 89.667Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.223 0.222 0.252
Expression system: Escherichia coli

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Citations

9 review citations

Skeletal muscle CaV1.1 channelopathies.
Flucher BE. (2020)
8 more

1 mention without citation

Structural insights into binding of STAC proteins to voltage-gated calcium channels.
Wong King Yuen et al. (2017)