› 6b35

Solution NMR

NMR ensemble of Tyrocidine A analogue AC3.28

Released:
DOI: 10.2210/pdb6b35/pdb
PDB entry 6b35 coloured by chain, ensemble of 8 models, front view.
PDB entry 6b35 coloured by chain, ensemble of 8 models, side view.
PDB entry 6b35 coloured by chain, ensemble of 8 models, top view.
Source organism: Brevibacillus brevis
Primary publication:
Tyrocidine A Analogues Bearing the Planar d-Phe-2-Abz Turn Motif: How Conformation Impacts Bioactivity.
Cameron AJ, Edwards PJB, Harjes E, Sarojini V
J Med Chem 60 9565-9574 (2017)
PMID: 29140694

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-166448 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Tyrocidine A analogue D-PHE-BE2-PHE-D-PHE-ASN-LYS-TYR-VAL-ORN-LEU Chain: A
Molecule details ›
Chain: A
Length: 10 amino acids
Theoretical weight: 1.31 KDa
Source organism: Brevibacillus brevis
Expression system: Not provided

Ligands and Environments

No bound ligands
3 modified residues:
Ligand DPN 2 x DPN
Ligand BE2 1 x BE2
Ligand ORN 1 x ORN

Experiments and Validation Details

Entry percentile scores
Chemical shift assignment: 45%
Refinement method: simulated annealing
Expression system: Not provided

Quick links

Citations

2 review citations

Antimicrobial Peptides: Classification, Design, Application and Research Progress in Multiple Fields.
Huan et al. (2020)
1 more