› 6b4l

X-ray diffraction
2.25Å resolution

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-170534 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Induced myeloid leukemia cell differentiation protein Mcl-1 Chains: A, B
Molecule details ›
Chains: A, B
Length: 157 amino acids
Theoretical weight: 17.88 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: Q07820 (Residues: 174-326; Coverage: 44%)
Gene names: BCL2L3, MCL1
Sequence domains: Apoptosis regulator proteins, Bcl-2 family
Structure domains: Blc2-like

Ligands and Environments

1 bound ligand:
Ligand CJY 2 x CJY
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: ALS BEAMLINE 5.0.1
Spacegroup: P21
Unit cell:
a: 46.89Å b: 82.929Å c: 48Å
α: 90° β: 117.5° γ: 90°
R-values:
R R work R free
0.22 0.218 0.258
Expression system: Escherichia coli

Quick links

Citations

26 review citations

Apoptosis as anticancer mechanism: function and dysfunction of its modulators and targeted therapeutic strategies.
Pistritto et al. (2016)
25 more

1 mention without citation

The Effect of Core Replacement on S64315, a Selective MCL-1 Inhibitor, and Its Analogues.
Sipos et al. (2021)