› 6b5v

Electron Microscopy
4.8Å resolution

Structure of TRPV5 in complex with econazole

Released:
DOI: 10.2210/pdb6b5v/pdb
PDB entry 6b5v coloured by chain, front view.
PDB entry 6b5v coloured by chain, side view.
PDB entry 6b5v coloured by chain, top view.
Source organism: Oryctolagus cuniculus
Primary publication:
Structural basis of TRPV5 channel inhibition by econazole revealed by cryo-EM.
Hughes TET, Lodowski DT, Huynh KW, Yazici A, Del Rosario J, Kapoor A, Basak S, Samanta A, Han X, Chakrapani S, Zhou ZH, Filizola M, Rohacs T, Han S, Moiseenkova-Bell VY
Nat Struct Mol Biol 25 53-60 (2018)
PMID: 29323279
Related structures: EMD-7058

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
homo tetramer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-195036 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Transient receptor potential cation channel subfamily V member 5 Chains: A, B, C, D
Molecule details ›
Chains: A, B, C, D
Length: 730 amino acids
Theoretical weight: 82.9 KDa
Source organism: Oryctolagus cuniculus
Expression system: Saccharomyces cerevisiae
UniProt:
  • Canonical: Q9XSM3 (Residues: 1-730; Coverage: 100%)
Gene names: Ecac1, Trpv5
Sequence domains:

Ligands and Environments

2 bound ligands:
Ligand ECL 4 x ECL
Ligand CA 1 x CA
No modified residues

Experiments and Validation Details

Entry percentile scores
Resolution: 4.8Å
Relevant EMDB volumes: EMD-7058
Expression system: Saccharomyces cerevisiae

Quick links

Citations

24 review citations

Cryo-EM in drug discovery: achievements, limitations and prospects.
Renaud et al. (2018)
23 more

12 mentions without citation

Structural insights into the gating mechanisms of TRPV channels.
Pumroy et al. (2020)
11 more