› 6bbi

X-ray diffraction
4.35Å resolution

The CRAC channel Orai in an unlatched-closed conformation; K163W loss-of-function mutation; P42212 crystal form

Released:
DOI: 10.2210/pdb6bbi/pdb
PDB entry 6bbi coloured by chain, front view.
PDB entry 6bbi coloured by chain, side view.
PDB entry 6bbi coloured by chain, top view.
Source organism: Drosophila melanogaster
Primary publication:
Structures reveal opening of the store-operated calcium channel Orai.
Hou X, Burstein SR, Long SB
Elife 7 (2018)
PMID: 30160233

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
homo hexamer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-193611 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Calcium release-activated calcium channel protein 1 Chains: A, B, C
Molecule details ›
Chains: A, B, C
Length: 214 amino acids
Theoretical weight: 24.28 KDa
Source organism: Drosophila melanogaster
Expression system: Komagataella pastoris
UniProt:
  • Canonical: Q9U6B8 (Residues: 133-341; Coverage: 60%)
Gene names: CG11430, CRACM1, Orai, olf186-F
Sequence domains: Mediator of CRAC channel activity

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: NSLS BEAMLINE X25
Spacegroup: P42212
Unit cell:
a: 118.697Å b: 118.697Å c: 122.419Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.308 0.306 0.329
Expression system: Komagataella pastoris

Quick links

Citations

18 review citations

Store-Operated Calcium Channels: From Function to Structure and Back Again.
Lewis RS. (2020)
17 more

2 mentions without citation

Structures reveal opening of the store-operated calcium channel Orai.
Hou et al. (2018)
1 more